| http://purl.uniprot.org/citations/16103228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16103228 | http://www.w3.org/2000/01/rdf-schema#comment | "Generation and turnover of phosphoinositides (PIs) must be coordinated in a spatial- and temporal-restricted manner. The small GTPase Rab5 interacts with two PI 3-kinases, Vps34 and PI3Kbeta, suggesting that it regulates the production of 3-PIs at various stages of the early endocytic pathway. Here, we discovered that Rab5 also interacts directly with PI 5- and PI 4-phosphatases and stimulates their activity. Rab5 regulates the production of phosphatidylinositol 3-phosphate (PtdIns[3]P) through a dual mechanism, by directly phosphorylating phosphatidylinositol via Vps34 and by a hierarchical enzymatic cascade of phosphoinositide-3-kinasebeta (PI3Kbeta), PI 5-, and PI 4-phosphatases. The functional importance of such an enzymatic pathway is demonstrated by the inhibition of transferrin uptake upon silencing of PI 4-phosphatase and studies in weeble mutant mice, where deficiency of PI 4-phosphatase causes an increase of PtdIns(3,4)P2 and a reduction in PtdIns(3)P. Activation of PI 3-kinase at the plasma membrane is accompanied by the recruitment of Rab5, PI 4-, and PI 5-phosphatases to the cell cortex. Our data provide the first evidence for a dual role of a Rab GTPase in regulating both generation and turnover of PIs via PI kinases and phosphatases to coordinate signaling functions with organelle homeostasis."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200505128"xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Hayashi M."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Wilm M."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Wenk M.R."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "De Camilli P."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Frankel W.N."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Solimena M."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Christoforidis S."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Uttenweiler-Joseph S."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Shin H.W."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Nystuen A."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Modregger J."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Lacas-Gervais S."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/author | "Hoepfner S."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/pages | "607-618"xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/title | "An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway."xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://purl.uniprot.org/core/volume | "170"xsd:string |
| http://purl.uniprot.org/citations/16103228 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16103228 |
| http://purl.uniprot.org/citations/16103228 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16103228 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXS5-mappedCitation-16103228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16103228 |