| http://purl.uniprot.org/citations/16107333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16107333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16107333 | http://www.w3.org/2000/01/rdf-schema#comment | "Combined phylogenetic and chromosomal location studies suggest that the orphan receptor RDC1 is related to CXC chemokine receptors. RDC1 provides a co-receptor function for a restricted number of human immunodeficiency virus (HIV) isolates, in particular for the CXCR4-using HIV-2 ROD strain. Here we show that CXCL12, the only known natural ligand for CXCR4, binds to and signals through RDC1. We demonstrate that RDC1 is expressed in T lymphocytes and that CXCL12-promoted chemotaxis is inhibited by an anti-RDC1 monoclonal antibody. Concomitant blockade of RDC1 and CXCR4 produced additive inhibitory effects in CXCL12-induced T cell migration. Furthermore, we provide evidence that interaction of CXCL12 with RDC1 is specific, saturable, and of high affinity (apparent KD approximately 0.4 nM). In CXCR4-negative cells expressing RDC1, CXCL12 promotes internalization of the receptor and chemotactic signals through RDC1. Collectively, our data indicate that RDC1, which we propose to rename as CXCR7, is a receptor for CXCL12."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m508234200"xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m508234200"xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Bachelerie F."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Bachelerie F."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Thelen M."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Thelen M."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Arenzana-Seisdedos F."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Arenzana-Seisdedos F."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Balabanian K."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Balabanian K."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Chow K.Y."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Chow K.Y."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Harriague J."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Harriague J."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Infantino S."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Infantino S."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Lagane B."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Lagane B."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Moepps B."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/author | "Moepps B."xsd:string |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16107333 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |