| http://purl.uniprot.org/citations/16107726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16107726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16107726 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of cytoplasmic dynein and microtubule dynamics is crucial for both mitotic cell division and neuronal migration. NDEL1 was identified as a protein interacting with LIS1, the protein product of a gene mutated in the lissencephaly. To elucidate NDEL1 function in vivo, we generated null and hypomorphic alleles of Ndel1 in mice by targeted gene disruption. Ndel1(-/-) mice were embryonic lethal at the peri-implantation stage like null mutants of Lis1 and cytoplasmic dynein heavy chain. In addition, Ndel1(-/-) blastocysts failed to grow in culture and exhibited a cell proliferation defect in inner cell mass. Although Ndel1(+/-) mice displayed no obvious phenotypes, further reduction of NDEL1 by making null/hypomorph compound heterozygotes (Ndel1(cko/-)) resulted in histological defects consistent with mild neuronal migration defects. Double Lis1(cko/+)-Ndel1(+/-) mice or Lis1(+/-)-Ndel1(+/-) mice displayed more severe neuronal migration defects than Lis1(cko/+)-Ndel1(+/)(+) mice or Lis1(+/-)-Ndel1(+/+) mice, respectively. We demonstrated distinct abnormalities in microtubule organization and similar defects in the distribution of beta-COP-positive vesicles (to assess dynein function) between Ndel1 or Lis1-null MEFs, as well as similar neuronal migration defects in Ndel1- or Lis1-null granule cells. Rescue of these defects in mouse embryonic fibroblasts and granule cells by overexpressing LIS1, NDEL1, or NDE1 suggest that NDEL1, LIS1, and NDE1 act in a common pathway to regulate dynein but each has distinct roles in the regulation of microtubule organization and neuronal migration."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.17.7812-7827.2005"xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.17.7812-7827.2005"xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Hirotsune S."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Hirotsune S."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Muramatsu M."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Muramatsu M."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Toyo-oka K."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Toyo-oka K."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Wynshaw-Boris A."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Wynshaw-Boris A."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Miyagawa S."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Miyagawa S."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Sasaki S."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Sasaki S."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Hiraiwa N."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Hiraiwa N."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Yoshiki A."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Yoshiki A."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Mori D."xsd:string |
| http://purl.uniprot.org/citations/16107726 | http://purl.uniprot.org/core/author | "Mori D."xsd:string |