| http://purl.uniprot.org/citations/16109369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16109369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16109369 | http://www.w3.org/2000/01/rdf-schema#comment | "In metazoans, microRNAs (miRNAs) carry out various regulatory functions through association with multiprotein miRNA-induced silencing complexes (miRISCs) that contain Dicer and Argonaute proteins. How miRNAs regulate the expression of their mRNA targets remains a major research question. We have identified the C. elegans ain-1 gene through a genetic suppressor screen and shown that it functions with the heterochronic genetic pathway that regulates developmental timing. Biochemical analysis indicates that AIN-1 interacts with protein complexes containing an Argonaute protein, Dicer, and miRNAs. AIN-1 shares homology with the candidate human neurological disease protein GW182, shown to localize in cytoplasmic processing bodies that are sites of mRNA degradation and storage. A functional AIN-1::GFP also localizes at the likely worm processing bodies. When coexpressed from transgenes, AIN-1 targets ALG-1 to the foci. These results suggest a model where AIN-1 regulates a subset of miRISCs by localization to the processing bodies, facilitating degradation or translational inhibition of mRNA targets."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.07.013"xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.07.013"xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/author | "Morita K."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/author | "Morita K."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/author | "Spencer A."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/author | "Spencer A."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/pages | "437-447"xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/pages | "437-447"xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/title | "The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/title | "The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/16109369 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16109369 |
| http://purl.uniprot.org/citations/16109369 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16109369 |