| http://purl.uniprot.org/citations/16109376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16109376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16109376 | http://www.w3.org/2000/01/rdf-schema#comment | "Brd4 is a mammalian bromodomain protein that binds to acetylated chromatin. Proteomic analysis revealed that Brd4 interacts with cyclinT1 and Cdk9 that constitutes core positive transcription elongation factor b (P-TEFb). Brd4 interacted with P-TEFb in the living nucleus through its bromodomain. About half of P-TEFb was bound to the inhibitory subunit and functionally inactive. Brd4 interacted with P-TEFb that was free of the inhibitory subunit. An increase in Brd4 expression led to increased P-TEFb-dependent phosphorylation of RNA polymerase II (RNAPII) CTD and stimulation of transcription from promoters in vivo. Conversely, a reduction in Brd4 expression by siRNA reduced CTD phosphorylation and transcription, revealing that Brd4 is a positive regulatory component of P-TEFb. In chromatin immunoprecipitation (ChIP) assays, the recruitment of P-TEFb to a promoter was dependent on Brd4 and was enhanced by an increase in chromatin acetylation. Together, P-TEFb alternately interacts with Brd4 and the inhibitory subunit to maintain functional equilibrium in the cell."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.06.027"xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.06.027"xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Mochizuki K."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Mochizuki K."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Brady J.N."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Brady J.N."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Ozato K."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Ozato K."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Jang M.K."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Jang M.K."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Jeong H.S."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/author | "Jeong H.S."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/pages | "523-534"xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/pages | "523-534"xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/title | "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription."xsd:string |
| http://purl.uniprot.org/citations/16109376 | http://purl.uniprot.org/core/title | "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription."xsd:string |