| http://purl.uniprot.org/citations/16109452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16109452 | http://www.w3.org/2000/01/rdf-schema#comment | "Data from animal studies and from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be involved in the mechanisms underlying substance abuse. The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with substance abuse. We studied this polymorphism in 103 methamphetamine- and 200 heroin-dependent cases and 122 normal controls. We also considered the association of this polymorphism with age of onset of substance abuse in the heroin-dependent cases. Significant differences in BDNF Val66Met genotype distribution were found between subjects dependent on methamphetamine (P = 0.046) or heroin (P = 0.045) and controls, suggesting that the lower 66Met carrier frequency is associated with substance abuse. Furthermore, in the heroin-dependent group, the Val/Val homozygotes had a later onset of substance abuse compared with the Met allele carriers. The results suggest that the BDNF Val66Met polymorphism or a nearby locus may be involved in the pathogenesis of substance abuse. Our findings support previous genetic scan results showing that BDNF may contribute to substance abuse vulnerability."xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molbrainres.2005.07.008"xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/author | "Cheng C.Y."xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/author | "Wu H.C."xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/author | "Chen T.J."xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/author | "Tsai S.J."xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/author | "Hong C.J."xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/author | "Yu Y.W."xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/pages | "86-90"xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/title | "Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males."xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://purl.uniprot.org/core/volume | "140"xsd:string |
| http://purl.uniprot.org/citations/16109452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16109452 |
| http://purl.uniprot.org/citations/16109452 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16109452 |
| http://purl.uniprot.org/uniprot/#_A0A0E3SU01-mappedCitation-16109452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16109452 |
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| http://purl.uniprot.org/uniprot/#_Q304R1-mappedCitation-16109452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16109452 |
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| http://purl.uniprot.org/uniprot/#_Q6T2C9-mappedCitation-16109452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16109452 |
| http://purl.uniprot.org/uniprot/#_Q96TC2-mappedCitation-16109452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16109452 |
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