| http://purl.uniprot.org/citations/16109736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16109736 | http://www.w3.org/2000/01/rdf-schema#comment | "Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor that has emerged as a critical mediator of endocrine function at multiple levels of the hypothalamic-pituitary-steroidogenic axis. Within the adrenal cortex, ACTH-dependent transcriptional responses, including transcriptional activation of several key steroidogenic enzymes within the steroid biosynthetic pathway, are largely dependent upon SF-1 action. The absence of a bona fide endogenous eukaryotic ligand for SF-1 suggests that signaling pathway activation downstream of the melanocortin 2 receptor (Mc2r) modulates this transcriptional response. We have used the chromatin immunoprecipitation assay to examine the temporal formation of ACTH-dependent transcription complexes on the Mc2r gene promoter. In parallel, ACTH-dependent signaling events were examined in an attempt to correlate transcriptional events with the upstream activation of signaling pathways. Our results demonstrate that ACTH-dependent signaling cascades modulate the temporal dynamics of SF-1-dependent complex assembly on the Mc2r promoter. Strikingly, the pattern of SF-1 recruitment and the subsequent attainment of active rounds of transcription support a kinetic model of SF-1 transcriptional activation, a model originally established in the context of ligand-dependent transcription by several classical nuclear hormone receptors. An assessment of the major ACTH-dependent signaling pathways highlights pivotal roles for the MAPK as well as the cAMP-dependent protein kinase A pathway in the entrainment of SF-1-mediated transcriptional events. In addition, the current study demonstrates that specific enzymatic activities are capable of regulating distinct facets of a highly ordered transcriptional response."xsd:string |
| http://purl.uniprot.org/citations/16109736 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2005-0215"xsd:string |
| http://purl.uniprot.org/citations/16109736 | http://purl.uniprot.org/core/author | "Hammer G.D."xsd:string |
| http://purl.uniprot.org/citations/16109736 | http://purl.uniprot.org/core/author | "Winnay J.N."xsd:string |
| http://purl.uniprot.org/citations/16109736 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16109736 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/16109736 | http://purl.uniprot.org/core/pages | "147-166"xsd:string |
| http://purl.uniprot.org/citations/16109736 | http://purl.uniprot.org/core/title | "Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation."xsd:string |
| http://purl.uniprot.org/citations/16109736 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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