| http://purl.uniprot.org/citations/16109846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16109846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16109846 | http://www.w3.org/2000/01/rdf-schema#comment | "The extensive somatic diversification of immune receptors is a hallmark of higher vertebrates. However, whether molecular diversity contributes to immune protection in invertebrates is unknown. We present evidence that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion molecule (Dscam). Secreted protein isoforms of Dscam were detected in the hemolymph, and hemocyte-specific loss of Dscam impaired the efficiency of phagocytic uptake of bacteria, possibly due to reduced bacterial binding. Importantly, the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1116887"xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1116887"xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Kondo M."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Kondo M."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Thomas F."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Thomas F."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Hughes M."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Hughes M."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Schmucker D."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Schmucker D."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Lamar D.L."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Lamar D.L."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Puettmann-Holgado R."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Puettmann-Holgado R."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Rebel V.I."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Rebel V.I."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Watson F.L."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Watson F.L."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/author | "Puttmann-Holgado R."xsd:string |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16109846 | http://purl.uniprot.org/core/name | "Science"xsd:string |