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| http://purl.uniprot.org/citations/16111640 | http://www.w3.org/2000/01/rdf-schema#comment | "Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic medullary epithelial cells. We demonstrate that the cellular mechanism by which Aire exerts its tolerance-promoting function is not primarily positive selection of regulatory T cells, but rather negative selection of T effector cells. Surprisingly, supplementing its influence on the transcription of genes encoding peripheral-tissue antigens, Aire somehow enhances the antigen-presentation capability of medullary epithelial cells. Thus, this transcriptional control element promotes central tolerance both by furnishing a specific thymic stromal cell type with a repertoire of self antigens and by better arming such cells to present these antigens to differentiating thymocytes. In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops."xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2005.07.005"xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/author | "Anderson M.S."xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/author | "Benoist C."xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/author | "Mathis D."xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/author | "Berzins S.P."xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/author | "Venanzi E.S."xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/pages | "227-239"xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/title | "The cellular mechanism of Aire control of T cell tolerance."xsd:string |
| http://purl.uniprot.org/citations/16111640 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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