| http://purl.uniprot.org/citations/16112029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16112029 | http://www.w3.org/2000/01/rdf-schema#comment | "Bee venom hypersensitivity is a clinical entity of outstanding importance because bee stings are a leading cause of mortality worldwide. Individuals with immediate-type bee venom hypersensitivity, beekeepers, and healthy controls were examined for HLA-DRB1, DQB1, and DQA1 alleles by sequence-specific oligonucleotide probe typing. Defined hypersensitivity to bee venom antigen phospholipase A2 (vbPLA2) is significantly associated with the presence of susceptible HLA class II alleles: DRB1*0101 (RR = 2.7, p < 3 x 10(-3)), DRB1*0103 (RR = 21.2, p < 7.5 x 10(-11)), DQA1*0101 (RR = 1.2, p < 38.52 x 10(-10)), and DQB1*0501 (RR = 4, p < 2.18 x 10(-10)). Some HLA class I alleles were also associated with risk to bee venom allergy: A*01 (RR = 2.4, p < 7.5 x 10(-4)), B*57 (RR = 35.1, p < 3.5 x 10(-7)), and B*5901 (p < 3.5 x 10(-5)), but they are probably of secondary significance. Three-(DRB1*0103-DQA1*0101-DQB1*0501) (RR = 21.24, p < 7.5 x 10(-11)) and five-loci (A*01-B*59-DRB1*0103-DQA1*0101-DQB1*0501) (p < 2.3 x 10(-6)) extended haplotypes are also significantly carried by vbPLA2 allergic patients. When HLA allele frequencies from patients are compared with those from beekeepers, only HLA-DRB1*0103 (RR = 11.7, p < 8.5 x 10(-5)) and HLA-DQA1*0101 (p < 0.02) were significantly increased in the former. These observations emphasize the importance of the DRB1*0103-DQA1*0101-DQB1*0501 haplotype as a strong candidate for susceptibility to vbPLA2 hypersensitivity, at least in our region."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2005.04.001"xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Suarez A."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Anton E."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Leyva-Cobian F."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Munoz D."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Duque S."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Ruiz de Alegria C."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Jimenez I."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Lopez-Hoyos M."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Garcia-Martin A."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Sanchez-Velasco P."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Alonso S.T."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Jerez J."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/author | "Martinez-Quesada J."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/pages | "818-825"xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/title | "Sensitivity to bee venom antigen phospholipase A2: association with specific HLA class I and class II alleles and haplotypes in beekeepers and allergic patients."xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/16112029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16112029 |
| http://purl.uniprot.org/citations/16112029 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16112029 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-16112029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16112029 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-16112029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16112029 |