| http://purl.uniprot.org/citations/16113298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16113298 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding HLA-restricted adaptive host immunity to defined epitopes of malarial antigens may be required for the development of successful malaria vaccines. Fourteen epitopes of preerythrocytic malarial antigens known to mediate cytotoxic T-lymphocyte responses against target cells expressing HLA-A2-restricted epitopes were synthesized and pooled based on antigen: thrombospondin-related anonymous protein (TRAP), circumsporozoite protein (CSP), and export protein 1 (Exp-1) peptides. HLA-A2 supertype (*0201, *0202, *0205, *6802) peripheral blood mononuclear cells collected from 774 Malian children, aged 3 months to 14 years, with severe Plasmodium falciparum malaria matched to uncomplicated malaria or healthy controls were stimulated with the HLA-A2-restricted peptide pools. Significant gamma interferon production, determined by enzyme-linked immunospot assay to at least one of the three peptide pools, was observed in 24/58 (41%) of the severe malaria cases, 24/57 (42%) of the uncomplicated malaria cases, and 34/51 (67%) of the healthy controls. Significant lymphoproliferation to these peptides was observed in 12/44 (27%) of the severe malaria cases, 13/55 (24%) of the uncomplicated malaria cases, and 18/50 (36%) of the healthy controls. Responses to individual peptide pools were limited. These studies confirm the presence of adaptive cell-mediated immunity to preerythrocytic malaria antigens in volunteers from Mali and demonstrate that suballeles of the HLA-A2 supertype can effectively present antigenic epitopes. However, whether these immune responses to TRAP, CSP, and Exp-1 malarial proteins play a substantial role in protection remains a matter of controversy."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.73.9.5799-5808.2005"xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Dao M."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Kone A."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Doumbo O.K."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Fernandez-Vina M.A."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Cissoko Y."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Plowe C.V."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Sangare L."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Lyke K.E."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Sztein M.B."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Burges R.B."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/author | "Diarra I."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/pages | "5799-5808"xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/title | "HLA-A2 supertype-restricted cell-mediated immunity by peripheral blood mononuclear cells derived from Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls."xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/16113298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16113298 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-16113298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16113298 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-16113298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16113298 |