| http://purl.uniprot.org/citations/16116428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16116428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16116428 | http://www.w3.org/2000/01/rdf-schema#comment | "Transmission ratio distortion in the mouse is caused by several t-complex distorters (Tcds) acting in trans on the t-complex responder (Tcr). Tcds additively affect the flagellar movement of all spermatozoa derived from t/+ males; sperm carrying Tcr are rescued, resulting in an advantage for t sperm in fertilization. Here we show that Tagap1, a GTPase-activating protein, can act as a distorter. Tagap1 maps to the Tcd1 interval and has four t loci, which encode altered proteins including a C-terminally truncated form. Overexpression of wild-type Tagap1 in sperm cells phenocopied Tcd function, whereas a loss-of-function Tagap1 allele reduced the transmission rate of the t6 haplotype. The combined data strongly suggest that the t loci of Tagap1 produce Tcd1a. Our results unravel the molecular nature of a Tcd and demonstrate the importance of small G proteins in transmission ratio distortion in the mouse."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1617"xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1617"xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/author | "Herrmann B.G."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/author | "Herrmann B.G."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/author | "Bauer H."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/author | "Bauer H."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/author | "Willert J."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/author | "Willert J."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/author | "Koschorz B."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/author | "Koschorz B."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/pages | "969-973"xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/pages | "969-973"xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/title | "The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/title | "The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice."xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/16116428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16116428 |
| http://purl.uniprot.org/citations/16116428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16116428 |