| http://purl.uniprot.org/citations/16116473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16116473 | http://www.w3.org/2000/01/rdf-schema#comment | "Tyrosine kinases of the Src family have been implicated in key biological processes. Here, we provide evidence that p56(Lck), a lymphoid-specific Src kinase, is involved in the activation of the mitochondrial apoptosis pathway. Lck-deficient T cells were completely resistant to anticancer drugs. In contrast, apoptosis sensitivity to death receptors was not altered, indicating a specific interference of Lck with the mitochondrial pathway. Re-expression of Lck restored sensitivity to drug-induced apoptosis and triggered mitochondrial cytochrome c release and caspase activation. Further analysis identified that the sensitization by Lck was independent of classical mediators of T-cell signaling, but essentially involved the Bcl-2 protein Bak. Expression of Bak was completely absent in Lck-deficient cells, while re-expression of Lck transcriptionally triggered Bak expression and conferred sensitivity to apoptosis, associated with a proapoptotic conformational change of Bak. Furthermore, in vitro the truncated fragment of Bid specifically activated Bak and cytochrome c release only from mitochondria of Lck-expressing cells. These results do not only demonstrate a sentinel role of Lck in drug resistance but also delineate a hitherto unknown pathway of Src kinases in regulation of Bcl-2 proteins."xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209034"xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/author | "Fischer U."xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/author | "Schulze-Osthoff K."xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/author | "Stroh C."xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/author | "Samraj A.K."xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/pages | "186-197"xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/title | "The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression."xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16116473 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16116473 |
| http://purl.uniprot.org/citations/16116473 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16116473 |
| http://purl.uniprot.org/uniprot/P06239#attribution-411169CFF8D72B04FF2BC5601B7847D7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16116473 |
| http://purl.uniprot.org/uniprot/P06239#attribution-A6077E1EB3B4E6E555B0F7EBEDE69A8D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16116473 |