| http://purl.uniprot.org/citations/16120575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16120575 | http://www.w3.org/2000/01/rdf-schema#comment | "To study the distribution of R219K polymorphism in ATP-Binding Cassette Transporter 1 (ABCA1) gene in Chinese Han population and the association of this polymorphism with coronary heart disease (CHD) . Genotypes were determined by PCR-RFLP approach in 417 unrelated healthy controls and 396 CHD patients. The frequencies of K allele and KK genotype for controls (0.465, 0.228) were significantly higher than those (0.381, 0.162) for patients (P<0.05). When the patients were divided into two subgroups by onset-age, the frequencies of K allele and KK genotype for early-onset patients (0.34, 0.111) were lower than those (0.419, 0.205) for late-onset patients and those for controls (P<0.05) , while there were no such differences between late-onset patients and controls. Patients with RR genotype had a higher plasma concentration of triglycerides (TG) when compared with that of KK genotype (P<0.05) . No significant differences of plasma high-density lipoprotein cholesterol (HDL-C) level were observed among patients with different genotypes. These data suggest that the R219K polymorphism in ABCA1 gene is correlated with CHD, and the ABCA1 gene KK genotype may has a function against atherosclerosis without detectable change of plasma HDL-C level in Chinese Han population."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/author | "Ma Y.X."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/author | "Zhang S.Z."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/author | "Dong J.T."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/author | "He G.P."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/name | "Yi Chuan"xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/pages | "549-522"xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/title | "[Relationship between the R219K polymorphism of ATP-binding cassette transporter 1 gene and coronary heart disease]."xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/16120575 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16120575 |
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| http://purl.uniprot.org/uniprot/#_Q59HC0-mappedCitation-16120575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120575 |
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