| http://purl.uniprot.org/citations/16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16120603 | http://www.w3.org/2000/01/rdf-schema#comment | "In contrast to hormone-dependent breast cancer, steroid hormone-induced proliferation in the normal mammary gland does not occur in the steroid-receptor positive cells but rather in adjacent cells via paracrine signaling involving several local growth factors. To help elucidate the mechanisms involved in the block in proliferation in hormone-receptor positive cells, we have utilized a CCAAT/enhancer binding protein (C/EBPbeta)-null mouse model. Loss of this transcription factor results in increased steroid and prolactin receptor expression concomitant with a 10-fold decrease in proliferation in response to pregnancy hormones. To determine the basis for this decrease, several markers of cell cycle progression were analyzed in wild type and C/EBPbeta-null mammary epithelial cells (MECs). These studies indicated that cell cycle progression in C/EBPbeta-null MECs is blocked at the G1/S transition. C/EBPbeta-null mammary glands display substantially increased levels of the activated form of transforming growth factor beta, a potent inhibitor of epithelial cell proliferation, as well as increased downstream Smad2 expression and signaling. While cyclin D1 levels were equivalent, cyclin E expression was markedly reduced in C/EBPbeta-null as compared with wildtype MECs. In addition, increased p27 stability and retention in the nucleus and decreased levels of the cdc25a phosphatase contributed to a significant loss of cdk2 kinase activity. Collectively, these changes prevent C/EBPbeta-null mammary epithelial cells from responding to hormone-induced proliferative signals."xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m508167200"xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/author | "Contreras A."xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/author | "Rosen J.M."xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/author | "Grimm S.L."xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/author | "Barcellos-Hoff M.H."xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/pages | "36301-36309"xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/title | "Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice."xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/16120603 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16120603 |
| http://purl.uniprot.org/citations/16120603 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16120603 |
| http://purl.uniprot.org/uniprot/#_P28033-mappedCitation-16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/#_Q3UGB9-mappedCitation-16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/#_O70192-mappedCitation-16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/#_Q3U6X7-mappedCitation-16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/#_P97377-mappedCitation-16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/#_Q3U307-mappedCitation-16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/#_Q3UPN9-mappedCitation-16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/#_Q6LD68-mappedCitation-16120603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/P28033 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/Q3UPN9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16120603 |
| http://purl.uniprot.org/uniprot/Q6LD68 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16120603 |