| http://purl.uniprot.org/citations/16123164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16123164 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisomes are the exclusive site for the beta-oxidation of very-long-chain fatty acids of more than 20 carbons in length (VLCFAs). Although the bulk of dietary long-chain fatty acids are oxidized in the mitochondria, VLCFAs cannot be catabolized in mitochondria and must be shortened first by peroxisomal beta-oxidation. The regulation of peroxisomal, mitochondrial, and microsomal fatty acid oxidation systems in liver is mediated principally by peroxisome proliferator-activated receptor alpha (PPARalpha). In this study we provide evidence that the liver X receptor (LXR) regulates the expression of the genetic program for peroxisomal beta-oxidation in liver. The genes encoding the three enzymes of the classic peroxisomal beta-oxidation cycle, acyl-coenzyme A (acyl-CoA) oxidase, enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase, are activated by the LXR ligand, T0901317. Accordingly, administration of T0901317 in mice promoted a dose-dependent and greater than 2-fold increase in the rate of peroxisomal beta-oxidation in the liver. The LXR effect is independent of PPARalpha, because T0901317-induced peroxisomal beta-oxidation in the liver of PPARalpha-null mice. Interestingly, T0901317-induced peroxisomal beta-oxidation is dependent on the LXRalpha isoform, but not the LXRbeta isoform. We propose that induction of peroxisomal beta-oxidation by LXR agonists may serve as a counterregulatory mechanism for responding to the hypertriglyceridemia and liver steatosis that is promoted by potent LXR agonists in vivo; however, additional studies are warranted."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2005-0591"xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Hu T."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Cao G."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Eacho P."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Christe M."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Michael L.F."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Michael M.D."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Ryan T."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Foxworthy P."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Ficorilli J.V."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/author | "Siesky A."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/pages | "5380-5387"xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/title | "Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha."xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/16123164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16123164 |
| http://purl.uniprot.org/citations/16123164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16123164 |
| http://purl.uniprot.org/uniprot/#_A2AGR4-mappedCitation-16123164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16123164 |
| http://purl.uniprot.org/uniprot/#_P23204-mappedCitation-16123164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16123164 |
| http://purl.uniprot.org/uniprot/#_Q542P9-mappedCitation-16123164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16123164 |