| http://purl.uniprot.org/citations/16123222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16123222 | http://www.w3.org/2000/01/rdf-schema#comment | "Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells and the integrin-mediated adhesive interactions of endothelial cells with extracellular matrix components such as fibronectin (FN). Recently, we demonstrated that alpha-defensins interfere with alpha5beta1-FN interactions and dependent endothelial cell functions. Here, alpha-defensins were studied in hypoxia-induced proliferative retinopathy. In vitro, alpha-defensins specifically inhibited alpha5beta1-integrin-dependent migration of bovine retinal endothelial cells (BRECs) to FN, attenuated the VEGF-stimulated increase in endothelial permeability, and blocked BREC proliferation and capillary sprout formation in 3-dimensional fibrin-matrices. An up-regulation of beta1-integrin and FN was observed in the retinal vessels in the mouse model of hypoxia-induced retinal angiogenesis. Systemic and local administration of alpha-defensins reduced retinal neovascularization by 45% and 60%, respectively, and this effect was comparable to the inhibitory effect of alpha5beta1-blocking antibody. alpha-Defensins were detected in human diabetic retinas associated with normal retinal vessels but were absent from proliferative lesions. Together, these data show that alpha-defensins inhibit pathologic retinal neovascularization in vivo and may provide a clinically efficient strategy against proliferative retinopathies."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-03-0889"xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Lubkowski J."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Hammes H.P."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Preissner K.T."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Chavakis T."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Bdeir K."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Cines D.B."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Fogt F."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Bdeir Y."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/author | "Economopoulou M."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/pages | "3831-3838"xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/title | "Inhibition of pathologic retinal neovascularization by alpha-defensins."xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/16123222 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16123222 |
| http://purl.uniprot.org/citations/16123222 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16123222 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQJ3-mappedCitation-16123222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16123222 |
| http://purl.uniprot.org/uniprot/#_D6RJL5-mappedCitation-16123222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16123222 |
| http://purl.uniprot.org/uniprot/#_P09055-mappedCitation-16123222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16123222 |
| http://purl.uniprot.org/uniprot/#_P11477-mappedCitation-16123222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16123222 |
| http://purl.uniprot.org/uniprot/#_Q8BY44-mappedCitation-16123222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16123222 |