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| http://purl.uniprot.org/citations/16125056 | http://www.w3.org/2000/01/rdf-schema#comment | "The Cbl protein functions both as a multivalent adaptor and a negative regulator of receptor tyrosine kinases (RTKs), the latter by directing polyubiquitination of RTKs. To study the function of Cbl in endothelial cell signalling and angiogenesis, wild-type Cbl and tyrosine kinase binding (TKB) domain mutated Cbl (G306E) were overexpressed in murine immortalised brain endothelial (IBE) cells. Wild-type Cbl cells exhibited enhanced proliferation in low serum compared with the control and G306E Cbl cells. Furthermore, up-regulated phosphorylation of fibroblast growth factor receptor 1 (FGFR-1) and Akt were observed in wild-type Cbl cells upon FGF-2 stimulation. A Cbl TKB domain mutant, G306E, disrupted the phosphorylation of the FGFR-1 but not that of FRS2. In the tubular morphogenesis assay, cells expressing wild-type Cbl initially formed tubular structures. These showed decreased stability and converted into cell aggregates, possibly due to a failure to cease proliferating. Our data support the idea that the wild-type Cbl cells exhibit enhanced proliferation, and thus lose their ability to differentiate appropriately. The present study reveals a role of the Cbl protein in FGF-2 dependent signalling in endothelial cells by its destabilisation of tubular structures."xsd:string |
| http://purl.uniprot.org/citations/16125056 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2005.03.005"xsd:string |
| http://purl.uniprot.org/citations/16125056 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/16125056 | http://purl.uniprot.org/core/author | "Welsh M."xsd:string |
| http://purl.uniprot.org/citations/16125056 | http://purl.uniprot.org/core/author | "Holmqvist K."xsd:string |
| http://purl.uniprot.org/citations/16125056 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16125056 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/16125056 | http://purl.uniprot.org/core/pages | "1433-1438"xsd:string |
| http://purl.uniprot.org/citations/16125056 | http://purl.uniprot.org/core/title | "A role of the protein Cbl in FGF-2-induced angiogenesis in murine brain endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/16125056 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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