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http://purl.uniprot.org/citations/16127295http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16127295http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

The dysregulated overexpression of BCL10 that results from a specific chromosomal translocation t(1;14)(p22;q32) in mucosa-associated lymphoid tissue lymphoma has been shown to activate nuclear factor (NF)-kappaB, which may promote growth and survival in tumor cells. Accordingly, the molecular mechanisms underlying NF-kappaB activation may be responsible for lymphomagenesis. The aim of this study was to determine the molecular mechanisms underlying NF-kappaB activation by BCL10 overexpression.

Methods

HeLa or COS-1 cells were transfected with BCL10, intracellular localization of BCL10 and the activation of NF-kappaB were analyzed.

Results

BCL10 expressed at a high level exhibited a filamentous distribution at the perinuclear region, whereas BCL10 at a low level of expression displayed a diffuse cytoplasmic distribution. Furthermore, the BCL10-mediated NF-kappaB activation was efficiently inhibited by a Ca2+ chelating agent or a Ca2+ channel blocker. We also found that amino acids (107-119) of BCL10 are required for the formation of filamentous structures at the perinuclear region and NF-kappaB activation.

Conclusion

These findings suggest that the filamentous pattern of overexpressed BCL10 at the perinuclear region adjacent to the endoplasmic reticulum is important for the BCL10-mediated NF-kappaB activation."xsd:string
http://purl.uniprot.org/citations/16127295http://purl.org/dc/terms/identifier"doi:10.1159/000086789"xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/author"Nakamura K."xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/author"Mori S."xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/author"Moriyama M."xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/author"Senda T."xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/author"Sato K."xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/name"Pathobiology"xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/pages"191-202"xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/title"Accumulation of BCL10 at the perinuclear region is required for the BCL10-mediated nuclear factor-kappa B activation."xsd:string
http://purl.uniprot.org/citations/16127295http://purl.uniprot.org/core/volume"72"xsd:string
http://purl.uniprot.org/citations/16127295http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16127295
http://purl.uniprot.org/citations/16127295http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16127295
http://purl.uniprot.org/uniprot/O95999#attribution-52EB3E5B8FB2C44E59EEFDF961A02A7Chttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/16127295
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http://purl.uniprot.org/uniprot/O95999http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16127295