| http://purl.uniprot.org/citations/16127449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16127449 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has essential roles in adipogenesis and glucose homeostasis, and is a molecular target of insulin-sensitizing drugs. Although the ability of PPAR-gamma agonists to antagonize inflammatory responses by transrepression of nuclear factor kappa B (NF-kappaB) target genes is linked to antidiabetic and antiatherogenic actions, the mechanisms remain poorly understood. Here we report the identification of a molecular pathway by which PPAR-gamma represses the transcriptional activation of inflammatory response genes in mouse macrophages. The initial step of this pathway involves ligand-dependent SUMOylation of the PPAR-gamma ligand-binding domain, which targets PPAR-gamma to nuclear receptor corepressor (NCoR)-histone deacetylase-3 (HDAC3) complexes on inflammatory gene promoters. This in turn prevents recruitment of the ubiquitylation/19S proteosome machinery that normally mediates the signal-dependent removal of corepressor complexes required for gene activation. As a result, NCoR complexes are not cleared from the promoter and target genes are maintained in a repressed state. This mechanism provides an explanation for how an agonist-bound nuclear receptor can be converted from an activator of transcription to a promoter-specific repressor of NF-kappaB target genes that regulate immunity and homeostasis."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature03988"xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Pascual G."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Rose D.W."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Perissi V."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Li A.C."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Willson T.M."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Fong A.L."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/author | "Gamliel A."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/pages | "759-763"xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/title | "A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma."xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://purl.uniprot.org/core/volume | "437"xsd:string |
| http://purl.uniprot.org/citations/16127449 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16127449 |
| http://purl.uniprot.org/citations/16127449 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16127449 |
| http://purl.uniprot.org/uniprot/Q60974#attribution-8D0FA7E7926E47F1C8A4595BFFAB6518 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16127449 |
| http://purl.uniprot.org/uniprot/O88907#attribution-3D2230EA3FAB8B084E401E08424CBFCC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16127449 |
| http://purl.uniprot.org/uniprot/P37238#attribution-8D0FA7E7926E47F1C8A4595BFFAB6518 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16127449 |
| http://purl.uniprot.org/uniprot/Q8BHJ5#attribution-3D2230EA3FAB8B084E401E08424CBFCC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16127449 |
| http://purl.uniprot.org/uniprot/Q8BHJ5#attribution-8D0FA7E7926E47F1C8A4595BFFAB6518 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16127449 |