| http://purl.uniprot.org/citations/16129707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16129707 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation NKG2D receptor has been shown to play an important role in the control of experimental tumor growth and metastases expressing ligands for NKG2D; however, a function for this recognition pathway in host protection from de novo tumorigenesis has never been demonstrated. We show that neutralization of NKG2D enhances the sensitivity of wild-type (WT) C57BL/6 and BALB/c mice to methylcholanthrene (MCA)-induced fibrosarcoma. The importance of the NKG2D pathway was additionally illustrated in mice deficient for either IFN-gamma or tumor necrosis factor-related apoptosis-inducing ligand, whereas mice depleted of natural killer cells, T cells, or deficient for perforin did not display any detectable NKG2D phenotype. Furthermore, IL-12 therapy preventing MCA-induced sarcoma formation was also largely dependent on the NKG2D pathway. Although NKG2D ligand expression was variable or absent on sarcomas emerging in WT mice, sarcomas derived from perforin-deficient mice were Rae-1(+) and immunogenic when transferred into WT syngeneic mice. These findings suggest an important early role for the NKG2D in controlling and shaping tumor formation."xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20050994"xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/author | "Hayakawa Y."xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/author | "Yokoyama W.M."xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/author | "Swann J."xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/author | "Cretney E."xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/author | "Zerafa N."xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/pages | "583-588"xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/title | "NKG2D function protects the host from tumor initiation."xsd:string |
| http://purl.uniprot.org/citations/16129707 | http://purl.uniprot.org/core/volume | "202"xsd:string |
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