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| http://purl.uniprot.org/citations/16135791 | http://www.w3.org/2000/01/rdf-schema#comment | "The Golgi-localized, Gamma-ear-containing, Arf-binding (GGA) proteins are monomeric clathrin adaptors that mediate the sorting of transmembrane cargo at the trans-Golgi network and endosomes. Here we report that one of these proteins, GGA3, becomes transiently phosphorylated upon activation of the epidermal growth factor (EGF) receptor. This phosphorylation takes place on a previously unrecognized site in the "hinge" segment of the protein, S368, and is strictly dependent on the constitutive phosphorylation of another site, S372. The EGF-induced phosphorylation of S368 does not require internalization of the EGF receptor or association of GGA3 with membranes. This phosphorylation can be blocked by inhibitors of both the mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways that function downstream of the activated EGF receptor. Phosphorylation of GGA3 on S368 causes an increase in the hydrodynamic radius of the protein, indicating a transition to a more asymmetric shape. Mutation of S368 and S372 to a phosphomimic aspartate residue decreases the association of GGA3 with membranes. These observations indicate that EGF signaling elicits phosphorylation events that regulate the association of GGA3 with organellar membranes."xsd:string |
| http://purl.uniprot.org/citations/16135791 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.18.7988-8000.2005"xsd:string |
| http://purl.uniprot.org/citations/16135791 | http://purl.uniprot.org/core/author | "Bonifacino J.S."xsd:string |
| http://purl.uniprot.org/citations/16135791 | http://purl.uniprot.org/core/author | "Mattera R."xsd:string |
| http://purl.uniprot.org/citations/16135791 | http://purl.uniprot.org/core/author | "Kametaka S."xsd:string |
| http://purl.uniprot.org/citations/16135791 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16135791 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16135791 | http://purl.uniprot.org/core/pages | "7988-8000"xsd:string |
| http://purl.uniprot.org/citations/16135791 | http://purl.uniprot.org/core/title | "Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes."xsd:string |
| http://purl.uniprot.org/citations/16135791 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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