| http://purl.uniprot.org/citations/16140745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16140745 | http://www.w3.org/2000/01/rdf-schema#comment | "Exposed seronegative individuals (ES) with persistent high-risk sexual behavior may be less susceptible to human immunodeficiency virus type 1 (HIV-1) infection because they carry the chemokine receptor (CR) gene alleles CCR5 open reading frame (ORF) Delta32, CCR5 promoter -2459G, or CCR2 ORF 64I (CCR2-64I), all of which have been found to diminish HIV-1 infectivity and/or disease progression. To investigate this, we determined the haplotypes for these three genetic loci in 93 ES and 247 low-risk control individuals. To test if protective haplotypes exert their effect by modulating CR expression, we measured the protein expression of CCR5 and CXCR4 on circulating CD4+ T cells and CD14+ monocytes in 71 ES and 92 controls. To avoid investigator bias, the analysis was performed without knowledge of each subject's risk and genotype. The CCR5 -2459G allele was significantly enriched in ES Caucasian men, who constituted the majority (84%) of the ES cohort, compared to the control Caucasian men (P = 0.02). This increase was mostly attributable to a higher frequency of the -2459 A/G versus the -2459 A/A genotype in individuals heterozygous for the delta32 allele (P = 0.012). No protective influence of the CCR2-64I allele was observed. The haplotypes CCR5 ORF delta32/CCR5 -2459A (in complete linkage disequilibrium) and CCR5 ORF wt/CCR5 -2459G had a cumulative negative effect on the expression of CCR5, since we measured significantly reduced CCR5 densities on both T-helper cells and monocytes only when both haplotypes were present. Densities of CCR5 on lymphocytes and monocytes were correlated (r = 0.59; P < 0.0001), indicating concordance of CCR5 expression patterns across different cell types. We conclude that the CCR5 ORF delta32/wt-CCR5 -2459 A/G genotype combination offers an advantage in resisting sexual HIV-1 transmission and that this effect is mediated by a relative paucity of CCR5 on potential target cells of HIV-1."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.18.11677-11684.2005"xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Zhu T."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Hwangbo Y."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "McElrath M.J."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Wilson S."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Greene B."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Hladik F."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Livingston-Rosanoff D."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Sakchalathorn P."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/author | "Speelmon E."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/pages | "11677-11684"xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/title | "Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission."xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/16140745 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16140745 |
| http://purl.uniprot.org/citations/16140745 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16140745 |
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| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-16140745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16140745 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-16140745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16140745 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-16140745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16140745 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-16140745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16140745 |