| http://purl.uniprot.org/citations/16140746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16140746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16140746 | http://www.w3.org/2000/01/rdf-schema#comment | "Simian virus 40 large T antigen (T Ag) is capable of immortalizing and transforming rodent cells. The transforming activity of T Ag is due in large part to perturbation of the tumor suppressor proteins p53 and the retinoblastoma (pRB) family members. Inactivation of these tumor suppressors may not be sufficient for T Ag-mediated cellular transformation. It has been shown that T Ag associates with an SCF-like complex that contains a member of the cullin family of E3 ubiquitin ligases, CUL7, as well as SKP1, RBX1, and an F-box protein, FBXW8. We identified T Ag residues 69 to 83 as required for T Ag binding to the CUL7 complex. We demonstrate that delta69-83 T Ag, while it lost its ability to associate with CUL7, retained binding to p53 and pRB family members. In the presence of CUL7, wild-type (WT) T Ag but not delta69-83 T Ag was able to induce proliferation of mouse embryo fibroblasts, an indication of cellular transformation. In contrast, WT and delta69-83 T Ag enabled mouse embryo fibroblasts to proliferate to similarly high densities in the absence of CUL7. Our data suggest that, in addition to p53 and the pRB family members, T Ag serves to bind to and inactivate the growth-suppressing properties of CUL7. In addition, these results imply that, at least in the presence of T Ag, CUL7 may function as a tumor suppressor."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.18.11685-11692.2005"xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.18.11685-11692.2005"xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "Arai T."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "Arai T."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "Ali S.H."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "Ali S.H."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "Kasper J.S."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "Kasper J.S."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "Kuwabara H."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/author | "Kuwabara H."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/pages | "11685-11692"xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/pages | "11685-11692"xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/title | "Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/title | "Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation."xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/16140746 | http://purl.uniprot.org/core/volume | "79"xsd:string |