| http://purl.uniprot.org/citations/16141224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16141224 | http://www.w3.org/2000/01/rdf-schema#comment | "The GATA factor Pannier (Pnr) activates proneural expression through binding to a remote enhancer of the achaete-scute (ac-sc) complex. Chip associates both with Pnr and with the (Ac-Sc)-Daughterless heterodimer bound to the ac-sc promoters to give a proneural complex that facilitates enhancer-promoter communication during development. Using a yeast two-hybrid screening, we have identified Toutatis (Tou), which physically interacts with both Pnr and Chip. Loss-of-function and gain-of-function experiments indicate that Tou cooperates with Pnr and Chip during neural development. Tou shares functional domains with chromatin remodelling proteins, including TIP5 (termination factor TTFI-interacting protein 5) of NoRC (nucleolar remodelling complex), which mediates repression of RNA polymerase 1 transcription. In contrast, Tou acts positively to activate proneural gene expression. Moreover, we show that Iswi associates with Tou, Pnr and Chip, and is also required during Pnr-driven neural development. The results suggest that Tou and Iswi may belong to a complex that directly regulates the activity of Pnr and Chip during enhancer-promoter communication, possibly through chromatin remodelling."xsd:string |
| http://purl.uniprot.org/citations/16141224 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02014"xsd:string |
| http://purl.uniprot.org/citations/16141224 | http://purl.uniprot.org/core/author | "Fromental-Ramain C."xsd:string |
| http://purl.uniprot.org/citations/16141224 | http://purl.uniprot.org/core/author | "Ramain P."xsd:string |
| http://purl.uniprot.org/citations/16141224 | http://purl.uniprot.org/core/author | "Vanolst L."xsd:string |
| http://purl.uniprot.org/citations/16141224 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16141224 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/16141224 | http://purl.uniprot.org/core/pages | "4327-4338"xsd:string |
| http://purl.uniprot.org/citations/16141224 | http://purl.uniprot.org/core/title | "Toutatis, a TIP5-related protein, positively regulates Pannier function during Drosophila neural development."xsd:string |
| http://purl.uniprot.org/citations/16141224 | http://purl.uniprot.org/core/volume | "132"xsd:string |
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