| http://purl.uniprot.org/citations/16143108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16143108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16143108 | http://www.w3.org/2000/01/rdf-schema#comment | "Dietary heme iron is an important nutritional source of iron in carnivores and omnivores that is more readily absorbed than non-heme iron derived from vegetables and grain. Most heme is absorbed in the proximal intestine, with absorptive capacity decreasing distally. We utilized a subtractive hybridization approach to isolate a heme transporter from duodenum by taking advantage of the intestinal gradient for heme absorption. Here we show a membrane protein named HCP 1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner. HCP 1 mRNA was highly expressed in duodenum and regulated by hypoxia. HCP 1 protein was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency. Our data indicate that HCP 1 is the long-sought intestinal heme transporter."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.06.025"xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.06.025"xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Takeuchi K."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Takeuchi K."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Simpson R.J."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Simpson R.J."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Oakhill J.S."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Oakhill J.S."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Anderson G.J."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Anderson G.J."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Khan Y."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Khan Y."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Vulpe C.D."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Vulpe C.D."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Latunde-Dada G.O."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Latunde-Dada G.O."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "McKie A.T."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "McKie A.T."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Hider R.C."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Hider R.C."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Shayeghi M."xsd:string |
| http://purl.uniprot.org/citations/16143108 | http://purl.uniprot.org/core/author | "Shayeghi M."xsd:string |