| http://purl.uniprot.org/citations/16146757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16146757 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMPs) play crucial roles in extravillous trophoblast invasion. In the present study, we examined the possible role of Smad4 and Smad2 in transforming growth factor (TGF)-beta1-induced MMP-2 expression, using the well-established invasive extravillous trophoblast cell line HTR-8/SVneo. Recombinant sense Smad4 or Smad2 retroviral vectors were constructed by inserting full-length Smad4 or Smad2 cDNA into pLXSN retroviral vector. Stable PT67 packaging cell clones were isolated and viral supernatants were used to infect HTR-8/SVneo cells. Effects of retroviral expression of Smad4 and Smad2 on TGF-beta1-regulated MMP-2 expression were assessed by semi-quantitative reverse transcription-polymerase chain reaction and gelatin zymography. The results showed that over-expression of Smad4 augmented MMP-2 mRNA abundance and the secretion of pro-MMP-2, and mimicked the inductive effect of TGF-beta1 on the production of MMP-2. However, retrovirus-mediated sense Smad2 gene transfer had no effect. These findings suggest that Smad4, but not Smad2, mediates TGF-beta1-induced MMP-2 expression in invasive extravillous trophoblasts."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.org/dc/terms/identifier | "doi:10.2741/1823"xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/author | "Lin H.Y."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/author | "Wang H.X."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/author | "Tsang B.K."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/author | "Wang H.M."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/author | "Qi J.G."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/name | "Front Biosci"xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/pages | "637-646"xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/title | "Involvement of SMAD4, but not of SMAD2, in transforming growth factor-beta1-induced trophoblast expression of matrix metalloproteinase-2."xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/16146757 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16146757 |
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| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-16146757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16146757 |
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