| http://purl.uniprot.org/citations/16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16151013 | http://www.w3.org/2000/01/rdf-schema#comment | "The Trp53 tumor suppressor gene product (p53) functions in the nucleus to regulate proapoptotic genes, whereas cytoplasmic p53 directly activates proapoptotic Bcl-2 proteins to permeabilize mitochondria and initiate apoptosis. Here, we demonstrate that a tripartite nexus between Bcl-xL, cytoplasmic p53, and PUMA coordinates these distinct p53 functions. After genotoxic stress, Bcl-xL sequestered cytoplasmic p53. Nuclear p53 caused expression of PUMA, which then displaced p53 from Bcl-xL, allowing p53 to induce mitochondrial permeabilization. Mutant Bcl-xL that bound p53, but not PUMA, rendered cells resistant to p53-induced apoptosis irrespective of PUMA expression. Thus, PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53."xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1114297"xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/author | "Newmeyer D.D."xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/author | "Chipuk J.E."xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/author | "Bouchier-Hayes L."xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/author | "Kuwana T."xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/pages | "1732-1735"xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/title | "PUMA couples the nuclear and cytoplasmic proapoptotic function of p53."xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://purl.uniprot.org/core/volume | "309"xsd:string |
| http://purl.uniprot.org/citations/16151013 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16151013 |
| http://purl.uniprot.org/citations/16151013 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16151013 |
| http://purl.uniprot.org/uniprot/Q99ML1#attribution-978C4ACED4AF084F99362184F41146A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A346XLN8-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A346XLS8-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |
| http://purl.uniprot.org/uniprot/#_A0A346XLT4-mappedCitation-16151013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16151013 |