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http://purl.uniprot.org/citations/16153173http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16153173http://www.w3.org/2000/01/rdf-schema#comment"Genome-wide studies of mRNA regulation and phenotypic responses have shown that eukaryotic cells mount a robust and multifaceted response upon exposure to DNA-damaging agents. The integration of theses studies over frameworks provided by protein-protein interactions, protein-DNA interactions, and subcellular localization information have led to the identification of networked responses to damage. Taken together, these studies illustrate that cellular protection from DNA and other macromolecular damage involves an intricate network of proteins involved in many different cellular functions, some of them expected (e.g., DNA repair and cell cycle checkpoints) but many of them unexpected (e.g., protein trafficking and degradation). This review highlights many of the studies that detail genome-wide responses to DNA-damaging agents and examines how these datasets have been used to build a systems view of cellular responses to damage."xsd:string
http://purl.uniprot.org/citations/16153173http://purl.org/dc/terms/identifier"doi:10.1146/annurev.micro.59.031805.133658"xsd:string
http://purl.uniprot.org/citations/16153173http://purl.uniprot.org/core/author"Samson L.D."xsd:string
http://purl.uniprot.org/citations/16153173http://purl.uniprot.org/core/author"Begley T.J."xsd:string
http://purl.uniprot.org/citations/16153173http://purl.uniprot.org/core/author"Fry R.C."xsd:string
http://purl.uniprot.org/citations/16153173http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16153173http://purl.uniprot.org/core/name"Annu Rev Microbiol"xsd:string
http://purl.uniprot.org/citations/16153173http://purl.uniprot.org/core/pages"357-377"xsd:string
http://purl.uniprot.org/citations/16153173http://purl.uniprot.org/core/title"Genome-wide responses to DNA-damaging agents."xsd:string
http://purl.uniprot.org/citations/16153173http://purl.uniprot.org/core/volume"59"xsd:string
http://purl.uniprot.org/citations/16153173http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16153173
http://purl.uniprot.org/citations/16153173http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16153173
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http://purl.uniprot.org/uniprot/#_P03069-mappedCitation-16153173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16153173
http://purl.uniprot.org/uniprot/#_Q03465-mappedCitation-16153173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16153173
http://purl.uniprot.org/uniprot/#_P20134-mappedCitation-16153173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16153173
http://purl.uniprot.org/uniprot/#_P32259-mappedCitation-16153173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16153173
http://purl.uniprot.org/uniprot/#_P33748-mappedCitation-16153173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16153173
http://purl.uniprot.org/uniprot/#_P33749-mappedCitation-16153173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16153173