| http://purl.uniprot.org/citations/16153868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16153868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16153868 | http://www.w3.org/2000/01/rdf-schema#comment | "Viral infection or stimulation of TLR3 triggers signaling cascades, leading to activation of the transcription factors IRF-3 and NF-kappaB, which collaborate to induce transcription of type I interferon (IFN) genes. In this study, we identified a protein termed VISA (for virus-induced signaling adaptor) as a critical component in the IFN-beta signaling pathways. VISA recruits IRF-3 to the cytoplasmic viral dsRNA sensor RIG-I. Depletion of VISA inhibits virus-triggered and RIG-I-mediated activation of IRF-3, NF-kappaB, and the IFN-beta promoter, suggesting that VISA plays a central role in virus-triggered TLR3-independent IFN-beta signaling. Our data also indicate that VISA interacts with TRIF and TRAF6 and mediates bifurcation of the TLR3-triggered NF-kappaB and IRF-3 activation pathways. These findings suggest that VISA is critically involved in both virus-triggered TLR3-independent and TLR3-mediated antiviral IFN signaling."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.08.014"xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.08.014"xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Zhai Z."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Zhai Z."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Wang Y.-Y."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Wang Y.-Y."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Xu L.-G."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Xu L.-G."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Shu H.-B."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Shu H.-B."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Han K.-J."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Han K.-J."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Li L.-Y."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/author | "Li L.-Y."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/pages | "727-740"xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/pages | "727-740"xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/title | "VISA is an adapter protein required for virus-triggered IFN-beta Signaling."xsd:string |
| http://purl.uniprot.org/citations/16153868 | http://purl.uniprot.org/core/title | "VISA is an adapter protein required for virus-triggered IFN-beta Signaling."xsd:string |