| http://purl.uniprot.org/citations/16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16155001 | http://www.w3.org/2000/01/rdf-schema#comment | "During schistosomiasis, parasite-derived glycoconjugates play a key role in manipulation of the host immune response, associated with persistence of the parasite. Among the candidate host receptors that are triggered by glycoconjugates are C-type lectins (CLRs) on dendritic cells (DCs), which in concerted action with Toll-like receptors determine the balance in DCs between induction of immunity versus tolerance. Here we report that the CLR DC-SIGN mediates adhesion of DCs to authentic glycolipids derived from Schistosoma mansoni cercariae and their excretory/secretory products. Structural characterization of the glycolipids, in combination with solid phase and cellular binding studies revealed that DC-SIGN binds to the carbohydrate moieties of both glycosphingolipid species with Galbeta1-4(Fucalpha1-3)GlcNAc (Lewis(X)) and Fucalpha1-3Galbeta1-4(Fucalpha1-3)GlcNAc (pseudo-Lewis(Y)) determinants. Importantly, these data indicate that surveying DCs in the skin may encounter schistosome-derived glycolipids immediately after infection. Recent analysis of crystals of the carbohydrate binding domain of DC-SIGN bound to Lewis(X) provided insight into the ability of DC-SIGN to bind fucosylated ligands. Using molecular modeling we showed that the observed binding of the schistosome-specific pseudo-Lewis(Y) to DC-SIGN is not directly compatible with the model described. To fit pseudo-Lewis(Y) into the model, the orientation of the side chain of Phe(313) in the secondary binding site of DC-SIGN was slightly changed, which results in a perfect stacking of Phe(313) with the hydrophobic side of the galactose-linked fucose of pseudo-Lewis(Y). We propose that pathogens such as S. mansoni may use the observed flexibility in the secondary binding site of DC-SIGN to target DCs, which may contribute to immune escape."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m507100200"xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/author | "Geyer R."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/author | "Imberty A."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/author | "Meyer S."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/author | "van Kooyk Y."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/author | "Geyer H."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/author | "van Die I."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/author | "van Liempt E."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/pages | "37349-37359"xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/title | "DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae, the first parasite-specific ligand of DC-SIGN."xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/16155001 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16155001 |
| http://purl.uniprot.org/citations/16155001 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16155001 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PIN7-mappedCitation-16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155001 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PJU2-mappedCitation-16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155001 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PJU9-mappedCitation-16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155001 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PMS7-mappedCitation-16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155001 |
| http://purl.uniprot.org/uniprot/#_A0A0H4Q180-mappedCitation-16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155001 |
| http://purl.uniprot.org/uniprot/#_B2R907-mappedCitation-16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155001 |
| http://purl.uniprot.org/uniprot/#_B4E2A8-mappedCitation-16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155001 |
| http://purl.uniprot.org/uniprot/#_M0QZG5-mappedCitation-16155001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155001 |