| http://purl.uniprot.org/citations/16155589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16155589 | http://www.w3.org/2000/01/rdf-schema#comment | "Actin polymerization is a key process for many cellular events during development. To a large extent, the formation of filamentous actin is controlled by the WASP and WAVE proteins that activate the Arp2/3 complex in different developmental processes. WAVE function is regulated through a protein complex containing Sra1, Kette and Abi. Using biochemical, cell biological and genetic tools, we show here that the Abi protein also has a central role in activating WASP-mediated processes. Abi binds WASP through its carboxy-terminal domain and acts as a potent stimulator of WASP-dependent F-actin formation. To elucidate the biological function of abi in Drosophila melanogaster, we studied bristle development, a process known to require wasp function. Reduction of abi function leads to a loss of bristles similar to that observed in wasp mutants. Activation of Abi results in the formation of ectopic bristles, a phenotype that is suppressed by a reduction of wasp activity but is not affected by the reduction of wave function. Thus, in vivo Abi may set the balance between WASP and WAVE in different actin-based developmental processes."xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1305"xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/author | "Stephan R."xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/author | "Klambt C."xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/author | "Bogdan S."xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/author | "Mertens A."xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/author | "Lobke C."xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/pages | "977-984"xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/title | "Abi activates WASP to promote sensory organ development."xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/16155589 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16155589 |
| http://purl.uniprot.org/citations/16155589 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16155589 |
| http://purl.uniprot.org/uniprot/A0A0B4KH51#attribution-63921196EBA9A3036E389DFAAFB160C0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16155589 |
| http://purl.uniprot.org/uniprot/Q9Y0S9#attribution-63921196EBA9A3036E389DFAAFB160C0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16155589 |
| http://purl.uniprot.org/uniprot/A0A0B4K774#attribution-63921196EBA9A3036E389DFAAFB160C0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16155589 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4K774-mappedCitation-16155589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155589 |
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| http://purl.uniprot.org/uniprot/#_M9NCT2-mappedCitation-16155589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155589 |
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| http://purl.uniprot.org/uniprot/#_H5V8D0-mappedCitation-16155589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16155589 |