| http://purl.uniprot.org/citations/16164023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16164023 | http://www.w3.org/2000/01/rdf-schema#comment | "Stabilin-1 is a type 1 transmembrane receptor specifically expressed by tissue macrophages and sinusoidal endothelial cells. We recently demonstrated that stabilin-1 is involved in the endocytic/recycling pathway and shuttles between the endosomal system and the trans-Golgi network (TGN) in human macrophages. In the present study, we designed a model cell system to study the mechanisms of stabilin-1-mediated endocytosis. Using CHO-K1 cells stably transfected with stabilin-1, we demonstrated that acetylated low-density lipoprotein (acLDL) induces recruitment of stabilin-1 into the endocytic pathway. Stabilin-1 mediates internalisation of acLDL and its delivery to early endosomes, and it is translocated together with its ligand to the late endosomal compartment. Treatment with wortmannin, a specific inhibitor of phosphatidylinositide 3-kinase (PI3K), did not block stabilin-1 mediated internalisation of acLDL as well as its trafficking to early endosomes, whereas it induced enlargement of stabilin-1/acLDL positive endosomes as well as partial dissociation of EEA1 from these structures. The major effect of wortmannin was the abrogation of stabilin-1/acLDL trafficking into the late endocytic pathway. In stabilin-1 positive human type 2 macrophages, wortmannin treatment resulted in formation of both enlarged and small stabilin-1 positive endosomes. This effect, however, was significantly weaker in macrophages as compared to CHO-stabilin-1 cells. Our data indicate that PI3K activity is required for the transfer of stabilin-1 and its ligand acLDL from early to late endosomal compartments."xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imbio.2005.05.022"xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/author | "Mamidi S."xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/author | "Kzhyshkowska J."xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/author | "Krusell L."xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/author | "Goerdt S."xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/author | "Gratchev A."xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/author | "Brundiers H."xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/name | "Immunobiology"xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/pages | "161-173"xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/title | "Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL."xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://purl.uniprot.org/core/volume | "210"xsd:string |
| http://purl.uniprot.org/citations/16164023 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16164023 |
| http://purl.uniprot.org/citations/16164023 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16164023 |
| http://purl.uniprot.org/uniprot/#_P09486-mappedCitation-16164023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16164023 |
| http://purl.uniprot.org/uniprot/#_P04114-mappedCitation-16164023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16164023 |
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| http://purl.uniprot.org/uniprot/Q9NY15 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16164023 |
| http://purl.uniprot.org/uniprot/P04114 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16164023 |
| http://purl.uniprot.org/uniprot/P09486 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16164023 |