| http://purl.uniprot.org/citations/16166635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16166635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16166635 | http://www.w3.org/2000/01/rdf-schema#comment | "BTB-kelch proteins can elicit diverse biological functions but very little is known about the physiological role of these proteins in vivo. Kelch-like protein 6 (KLHL6) is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. In the B-lymphocyte lineage, KLHL6 is expressed throughout ontogeny, and KLHL6 expression is strongly upregulated in germinal center (GC) B cells. To analyze the role of KLHL6 in vivo, we have generated mouse mutants of KLHL6. Development of pro- and pre-B cells was normal but numbers of subsequent stages, transitional 1 and 2, and mature B cells were reduced in KLHL6-deficient mice. The antigen-dependent GC reaction was blunted (smaller GCs, reduced B-cell expansion, and reduced memory antibody response) in the absence of KLHL6. Comparison of mutants with global loss of KLHL6 to mutants lacking KLHL6 specifically in B cells demonstrated a B-cell-intrinsic requirement for KLHL6 expression. Finally, B-cell antigen receptor (BCR) cross-linking was less sensitive in KLHL6-deficient B cells compared to wild-type B cells as measured by proliferation, Ca2+ response, and activation of phospholipase Cgamma2. Our results strongly point to a role for KLHL6 in BCR signal transduction and formation of the full germinal center response."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.19.8531-8540.2005"xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.19.8531-8540.2005"xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Miyazaki T."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Miyazaki T."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Caprioli A."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Caprioli A."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Sato T.N."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Sato T.N."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Rodewald H.-R."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Rodewald H.-R."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Waskow C."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Waskow C."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Kroll J."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Kroll J."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Lin K.-M."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Lin K.-M."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Liu H.-H."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/author | "Liu H.-H."xsd:string |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16166635 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |