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http://purl.uniprot.org/citations/16166642http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16166642http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16166642http://www.w3.org/2000/01/rdf-schema#comment"We report the identification and characterization of JAMP (JNK1 [Jun N-terminal kinase 1]-associated membrane protein), a predicted seven-transmembrane protein that is localized primarily within the plasma membrane and associates with JNK1 through its C-terminal domain. JAMP association with JNK1 outcompetes JNK1 association with mitogen-activated protein kinase phosphatase 5, resulting in increased and prolonged JNK1 activity following stress. Elevated expression of JAMP following UV or tunicamycin treatment results in sustained JNK activity and a higher level of JNK-dependent apoptosis. Inhibition of JAMP expression by RNA interference reduces the degree and duration of JNK activation and concomitantly the level of stress-induced apoptosis. Through its regulation of JNK1 activity, JAMP emerges as a membrane-anchored regulator of the duration of JNK1 activity in response to diverse stress stimuli."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.org/dc/terms/identifier"doi:10.1128/mcb.25.19.8619-8630.2005"xsd:string
http://purl.uniprot.org/citations/16166642http://purl.org/dc/terms/identifier"doi:10.1128/mcb.25.19.8619-8630.2005"xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Asahara T."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Asahara T."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Bhoumik A."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Bhoumik A."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Ronai Z."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Ronai Z."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Broday L."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Broday L."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Tcherpakov M."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Tcherpakov M."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Bromberg K.D."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Bromberg K.D."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Didier C."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Didier C."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Kadoya T."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Kadoya T."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Khurana A."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/author"Khurana A."xsd:string
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16166642http://purl.uniprot.org/core/date"2005"xsd:gYear