| http://purl.uniprot.org/citations/16170304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16170304 | http://www.w3.org/2000/01/rdf-schema#comment | "A reduction-of-function mutation in ect-2 was isolated as a suppressor of the Multivulva phenotype of a lin-31 mutation. Analysis using markers indicates that this mutation causes defects in both the cytokinesis and migration of epidermal P cells, phenotypes similar to those caused by expressing a rho-1 dominant-negative construct. ect-2 encodes the Caenorhabditis elegans orthologue of the mouse Ect2 and Drosophila Pebble that function as guanine nucleotide exchange factors (GEFs) for Rho GTPases. The ect-2Colon, two colonsGFP reporter is expressed in embryonic cells and P cells. RNA interference of ect-2 causes sterility and embryonic lethality, in addition to the P-cell defects. We have determined the lesions of two ect-2 alleles, and described their differences in phenotypes in specific tissues. We propose a model in which ECT-2GEF not only activates RHO-1 for P-cell cytokinesis, but also collaborates with UNC-73GEF and at least two Rac proteins to regulate P-cell migration."xsd:string |
| http://purl.uniprot.org/citations/16170304 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400533"xsd:string |
| http://purl.uniprot.org/citations/16170304 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/16170304 | http://purl.uniprot.org/core/author | "Morita K."xsd:string |
| http://purl.uniprot.org/citations/16170304 | http://purl.uniprot.org/core/author | "Hirono K."xsd:string |
| http://purl.uniprot.org/citations/16170304 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16170304 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/16170304 | http://purl.uniprot.org/core/pages | "1163-1168"xsd:string |
| http://purl.uniprot.org/citations/16170304 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells."xsd:string |
| http://purl.uniprot.org/citations/16170304 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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