| http://purl.uniprot.org/citations/16172262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16172262 | http://www.w3.org/2000/01/rdf-schema#comment | "Experimental allergic encephalomyelitis (EAE) serves as a model for multiple sclerosis and is considered to be a CD4+ Th1 cell-mediated autoimmune disease. To investigate the role of platelet-activating factor (PAF) in this disease, PAF receptor (PAFR) KO (PAFR-KO) and wild-type (WT) mice, on a C57BL/6 genetic background, were immunized with myelin oligodendrocyte glycoprotein 35-55. The levels of PAF production and PAFR mRNA expression in the spinal cord (SC) correlated with the EAE symptoms. PAFR-KO mice showed lower incidence and less severe symptoms in the chronic phase of EAE than WT mice. However, no difference was observed in T cell proliferation, Th1-cytokine production, or titer of IgG2a between both genotypes. Before onset, as revealed by microarray analysis, mRNAs of inflammatory mediators and their receptors-including IL-6 and CC chemokine receptor 2-were down-regulated in the SC of PAFR-KO mice compared with WT mice. Moreover, in the chronic phase, the severity of inflammation and demyelination in the SC was substantially reduced in PAFR-KO mice. PAFR-KO macrophages reduced phagocytic activity and subsequent production of TNF-alpha. These results suggest that PAF plays a dual role in EAE pathology in the induction and chronic phases through the T cell-independent pathways."xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20050660"xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/author | "Ishii S."xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/author | "Shimada A."xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/author | "Kita Y."xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/author | "Toda A."xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/author | "Kihara Y."xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/pages | "853-863"xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/title | "Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor."xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://purl.uniprot.org/core/volume | "202"xsd:string |
| http://purl.uniprot.org/citations/16172262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16172262 |
| http://purl.uniprot.org/citations/16172262 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16172262 |
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