| http://purl.uniprot.org/citations/16175505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16175505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16175505 | http://www.w3.org/2000/01/rdf-schema#comment | "Family history is a major risk factor for myocardial infarction (MI). However, known gene variants associated with MI cannot fully explain the genetic component of MI risk. We hypothesized that a gene-centric association study that was not limited to candidate genes could identify novel genetic associations with MI. We studied 11,053 single-nucleotide polymorphisms (SNPs) in 6,891 genes, focusing on SNPs that could influence gene function to increase the likelihood of identifying disease-causing gene variants. To minimize false-positive associations generated by multiple testing, two studies were used to identify a limited number of nominally associated SNPs; a third study tested the hypotheses that these SNPs are associated with MI. In the initial study (of 340 cases and 346 controls), 637 SNPs were associated with MI (P<.05); these were evaluated in a second study (of 445 cases and 606 controls), and 31 of the 637 SNPs were associated with MI (P<.05) and had the same risk allele as in the first study. For each of these 31 SNPs, we tested the hypothesis that it is associated with MI, using a third study (of 560 cases and 891 controls). We found that four of these gene variants were associated with MI (P<.05; false-discovery rate <10%) and had the same risk allele as in the first two studies. These gene variants encode the cytoskeletal protein palladin (KIAA0992 [odds ratio (OR) 1.40]), a tyrosine kinase (ROS1 [OR 1.75]), and two G protein-coupled receptors (TAS2R50 [OR 1.58] and OR13G1 [OR 1.40]); all ORs are for carriers of two versus zero risk alleles. These findings could lead to a better understanding of MI pathophysiology and improved patient risk assessment."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.org/dc/terms/identifier | "doi:10.1086/491674"xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.org/dc/terms/identifier | "doi:10.1086/491674"xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Catanese J.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Catanese J.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Shiffman D."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Shiffman D."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Topol E.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Topol E.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Kane J.P."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Kane J.P."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Malloy M.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Malloy M.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Pullinger C.R."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Pullinger C.R."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Luke M.M."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Luke M.M."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Devlin J.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Devlin J.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Leong D.U."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Leong D.U."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Sninsky J.J."xsd:string |
| http://purl.uniprot.org/citations/16175505 | http://purl.uniprot.org/core/author | "Sninsky J.J."xsd:string |