| http://purl.uniprot.org/citations/16176931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16176931 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hsp70 family member mortalin (mot-2/mthsp70/GRP75) binds to a carboxyl terminus region of the tumor suppressor protein p53. By in vivo co-immunoprecipitation of mot-2 with p53 and its deletion mutants, we earlier mapped the mot-2-binding site of p53 to its carboxyl terminus 312-352 amino acid residues. In the present study we attempted to disrupt mot-2-p53 interactions by overexpression of short p53 carboxyl-terminal peptides. We report that p53 carboxyl-terminal peptides (amino acid residues 312-390, 312-352, 323-390, and 323-352) localize in the cytoplasm, whereas 312-322, 337-390, 337-352, and 352-390 locate mostly in the nucleus. Most interestingly, the cytoplasmically localizing p53 peptides harboring the residues 323-337 activated the endogenous p53 function by displacing it from p53-mortalin complexes and relocating it to the nucleus. Such activation of p53 function was sufficient to cause growth arrest of human osteosarcoma and breast carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m500022200"xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/author | "Kaur K."xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/author | "Aida S."xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/author | "Kaul S.C."xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/author | "Wadhwa R."xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/author | "Yaguchi T."xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/pages | "39373-39379"xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/title | "Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides."xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/16176931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16176931 |
| http://purl.uniprot.org/citations/16176931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16176931 |
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| http://purl.uniprot.org/uniprot/#_B7Z4T3-mappedCitation-16176931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16176931 |
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