| http://purl.uniprot.org/citations/16179351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16179351 | http://www.w3.org/2000/01/rdf-schema#comment | "Superoxide dismutases (SODs) are important antioxidant enzymes responsible for the elimination of superoxide radical (O(2)(-)). The manganese-containing SOD (Mn-SOD) has been suggested to have tumor suppressor function and is located in the mitochondria where the majority of O(2)(-) is generated during respiration. Although increased reactive oxygen species (ROS) in cancer cells has long been recognized, the expression of Mn-SOD in cancer and its role in cancer development remain elusive. The present study used a human tissue microarray to analyze Mn-SOD expression in primary ovarian cancer tissues, benign ovarian lesions, and normal ovary epithelium. Significantly higher levels of Mn-SOD protein expression were detected in the malignant tissues compared with normal tissues (p < 0.05). In experimental systems, suppression of Mn-SOD expression by small interfering RNA caused a 70% increase of superoxide in ovarian cancer cells, leading to stimulation of cell proliferation in vitro and more aggressive tumor growth in vivo. Furthermore, stimulation of mitochondrial O(2)(-) production induced an increase of Mn-SOD expression. Our findings suggest that the increase in Mn-SOD expression in ovarian cancer is a cellular response to intrinsic ROS stress and that scavenging of superoxide by SOD may alleviate the ROS stress and thus reduce the simulating effect of ROS on cell growth."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m503296200"xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/author | "Huang P."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/author | "Yang G."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/author | "Rosen D.G."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/pages | "39485-39492"xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/title | "Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/16179351 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16179351 |
| http://purl.uniprot.org/citations/16179351 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16179351 |
| http://purl.uniprot.org/uniprot/P04179#attribution-75EDA5A37468D9A88372722B0486149A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16179351 |
| http://purl.uniprot.org/uniprot/#_A0A4Y1U5T0-mappedCitation-16179351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16179351 |
| http://purl.uniprot.org/uniprot/#_A0A4Y1U5Z3-mappedCitation-16179351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16179351 |
| http://purl.uniprot.org/uniprot/#_A0A384NL29-mappedCitation-16179351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16179351 |
| http://purl.uniprot.org/uniprot/#_A0A4Y1U0K4-mappedCitation-16179351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16179351 |
| http://purl.uniprot.org/uniprot/#_A0A4Y1U1I6-mappedCitation-16179351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16179351 |
| http://purl.uniprot.org/uniprot/#_A0A4Y1U1P4-mappedCitation-16179351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16179351 |
| http://purl.uniprot.org/uniprot/#_A0A4Y1U3J6-mappedCitation-16179351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16179351 |