| http://purl.uniprot.org/citations/16182248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16182248 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factor-1 (HIF-1), which consists of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability. The mouse inhibitory PAS (Per/Arnt/Sim) domain protein (IPAS) functions as a negative regulator in HIF-mediated gene expression. In this report, we cloned the human orthologs of the mouse IPAS gene, IPASH1 and IPASH2, to further study the regulatory mechanism of HIF-1 by the IPAS proteins. The human IPAS proteins inhibited the transactivation function of HIF-1alpha under hypoxic conditions. In addition, human IPAS proteins blocked the hypoxia-induced VEGF expression and inhibited cell migration and tube formation of human umbilical vein endothelial cells. Interestingly, both HIF-1alpha and HIF-1beta interacted with the IPAS proteins. Collectively, these results suggest that human IPAS proteins inhibit angiogenesis by binding to and inhibiting HIF-1alpha and HIF-1beta."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.09.038"xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/author | "Lee J.A."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/author | "Lee D.H."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/author | "Park B.C."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/author | "Park S.G."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/author | "Cho S."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/author | "Park J.E."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/author | "Jang M.S."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/author | "Myung P.K."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/pages | "209-215"xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/title | "Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins."xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://purl.uniprot.org/core/volume | "337"xsd:string |
| http://purl.uniprot.org/citations/16182248 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16182248 |
| http://purl.uniprot.org/citations/16182248 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16182248 |
| http://purl.uniprot.org/uniprot/#_B2RBI6-mappedCitation-16182248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16182248 |
| http://purl.uniprot.org/uniprot/#_B4DSD9-mappedCitation-16182248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16182248 |
| http://purl.uniprot.org/uniprot/#_B4E3J3-mappedCitation-16182248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16182248 |
| http://purl.uniprot.org/uniprot/#_O95262-mappedCitation-16182248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16182248 |
| http://purl.uniprot.org/uniprot/#_H0YDZ5-mappedCitation-16182248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16182248 |
| http://purl.uniprot.org/uniprot/#_M0R104-mappedCitation-16182248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16182248 |
| http://purl.uniprot.org/uniprot/#_Q9UPH7-mappedCitation-16182248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16182248 |