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http://purl.uniprot.org/citations/16185849http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16185849http://www.w3.org/2000/01/rdf-schema#comment"

Background

Some studies suggested that human HLA status may potentiate development of the AA phenotype and exists ethic differences. No report has been published about HLA class I alleles associated with AA in Chinese Hans.

Objective

To study the distribution of HLA class I alleles and haplotypes in Chinese Hans AA patients and the relation of HLA class I profile with age of onset, severity, duration of current attack, past history and family history.

Methods

The polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA class I alleles in 192 patients with AA and 252 healthy controls in Chinese Hans.

Results

The frequencies of HLA-A*02, -A*03, -B*18, -B*27, -B*52 and -Cw*0704 were significantly higher in patients than in controls. The A*2-B*18, A*2-B*27, A*2-B*52, A*2-Cw*0704, B*18-Cw*0704, B*27-Cw*0704, B*52-Cw*0704 were found as high-risk haplotypes in developing AA in this study. The HLA-A*02 and -A*03 were observed increased frequencies in patients less than 50% hair loss, and HLA-B*27 equally in patients of 50-99% hair loss, alopecia totalis and alopecia universalis. The frequencies of HLA-A*02 and -B*27 were significantly raised in recurrent patients, and ones of HLA-A*02, -A*03 and -B*27 similarly in patients without a positive family history.

Conclusion

This study demonstrated the positive association of HLA class I alleles and haplotypes with AA. There may be differences in genetic background in patients with different age of onset, grade of scalp hair loss, duration of current attack, a past history and a family history."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.org/dc/terms/identifier"doi:10.1016/j.jdermsci.2005.07.008"xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Fan X."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Gao M."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Yang S."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Zhu Y.G."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Zhang X.J."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Cui Y."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Wang P.G."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Chen J.J."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Liang Y.H."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Sun L.D."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Xiao F.L."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Zhou F.S."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Du W.H."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Yan K.L."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/author"Zhou S.M."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/name"J Dermatol Sci"xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/pages"109-119"xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/title"Association of HLA class I alleles with aloplecia areata in Chinese Hans."xsd:string
http://purl.uniprot.org/citations/16185849http://purl.uniprot.org/core/volume"41"xsd:string
http://purl.uniprot.org/citations/16185849http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16185849
http://purl.uniprot.org/citations/16185849http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16185849
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