| http://purl.uniprot.org/citations/16186106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16186106 | http://www.w3.org/2000/01/rdf-schema#comment | "The nucleolus is the site of ribosomal DNA (rDNA) transcription and ribosome production. In exploring the role of nucleolar protein MCRS1 (microspherule protein1)/MSP58 (58-kDa microspherule protein), we found that Mi-2beta, a component of a nucleosome remodeling and deacetylase (NuRD) complex, RET finger protein (RFP), and upstream binding factor (UBF) were associated with MCRS1. Yeast two-hybrid assays revealed that MCRS1 bound to the ATPase/helicase region of Mi-2beta and the coiled-coil region of RFP. Interestingly, confocal microscopic analyses revealed the co-localization of MCRS1, Mi-2beta, RFP, and the rRNA transcription factor UBF in the nucleoli. We also found that MCRS1, Mi-2beta, and RFP were associated with rDNA using a chromatin immunoprecipitation assay. Finally, we showed that MCRS1, Mi-2beta, and RFP up-regulated transcriptional activity of the rDNA promoter and that ribosomal RNA transcription was repressed when MCRS1, Mi-2beta, and RFP expression was reduced using siRNA. These results indicated that Mi-2beta and RFP, known to be involved in transcriptional repression in the nucleus, co-localize with MCRS1 in the nucleolus and appear to activate the rRNA transcription."xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m507356200"xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/author | "Shimono Y."xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/author | "Shimono K."xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/author | "Ishiguro N."xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/author | "Shimokata K."xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/pages | "39436-39447"xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/title | "Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription."xsd:string |
| http://purl.uniprot.org/citations/16186106 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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