| http://purl.uniprot.org/citations/16186475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16186475 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundFactor V Leiden homozygosity predisposes patients to deep venous thrombosis and major pulmonary thromboembolism. Consequently, factor V Leiden homozygosity could, via unrecognized repeated minor pulmonary thromboemboli, cause chronic pulmonary disease. We tested the hypothesis that factor V Leiden homozygosity is associated with pulmonary symptoms and signs.MethodsWe studied a general population sample of 9253 individuals from the Copenhagen City Heart Study who were examined in 1991-1994. Of these, 6475 participants were also examined in 1976-1978 and/or 1981-1983. End points were dyspnea and lung function.ResultsAmong 20 factor V Leiden homozygotes, a mean +/- SD of 32% +/-11% had severe dyspnea compared with 6% +/-0.3% of 8534 noncarriers (chi(2) test; P<.001). The corresponding adjusted odds ratio for severe dyspnea was 5.4 (95% confidence interval, 1.9-15.7). During follow-up, forced expiratory volume in 1 second and forced vital capacity were 5% to 10% lower in homozygotes vs noncarriers (analysis of variance; P = .003 and P = .03). The annual mean +/-SD loss of forced expiratory volume in 1 second and forced vital capacity was 39 +/- 8 mL/y and 35 +/- 8 mL/y in homozygotes vs 21 +/- 10 mL/y and 15 +/-10 mL/y in noncarriers (t test; P = .03 and P = .04), respectively. Factor V Leiden heterozygosity (n = 699) did not influence pulmonary symptoms and signs.ConclusionWe demonstrate a previously unrecognized clinical presentation of factor V Leiden homozygosity with severe dyspnea and decreased pulmonary function."xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.org/dc/terms/identifier | "doi:10.1001/archinte.165.17.2032"xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/author | "Lange P."xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/author | "Nordestgaard B.G."xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/author | "Tybjaerg-Hansen A."xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/author | "Vestbo J."xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/author | "Juul K."xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/author | "Mortensen J."xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/name | "Arch Intern Med"xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/pages | "2032-2036"xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/title | "Factor V leiden homozygosity, dyspnea, and reduced pulmonary function."xsd:string |
| http://purl.uniprot.org/citations/16186475 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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