| http://purl.uniprot.org/citations/16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16186799 | http://www.w3.org/2000/01/rdf-schema#comment | "The v-rel oncogene is the most efficient transforming member of the Rel/NF-kappaB family of transcription factors. v-Rel induces avian and mammalian lymphoid cell tumors and transforms chicken embryo fibroblasts in culture by the aberrant regulation of genes under the control of Rel/NF-kappaB proteins. Here we report that the expression of SH3BGRL, a member of the SH3BGR (SH3 domain-binding glutamic acid-rich) family of proteins, is downregulated in v-Rel-expressing fibroblasts, lymphoid cells, and splenic tumor cells. Chromatin immunoprecipitation experiments demonstrated that v-Rel binds to the sh3bgrl promoter in transformed cells. Coexpression of SH3BGRL with v-Rel in primary splenic lymphocytes reduced the number of colonies formed by 76%. Mutations in the predicted SH3-binding domain of SH3BGRL abolished the suppressive effect on v-Rel transformation and resulted in colony numbers comparable to those formed by v-Rel alone. However, mutations in the predicted EVH1-binding domain of SH3BGRL only had a modest effect on suppression of v-Rel transformation. This study provides the first example of a gene that is downregulated in v-Rel-expressing cells that also plays a role in v-Rel transformation."xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209107"xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/author | "You M."xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/author | "Liss A.S."xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/author | "Bose H.R."xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/author | "Majid S.M."xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/pages | "756-768"xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/title | "The suppression of SH3BGRL is important for v-Rel-mediated transformation."xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16186799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16186799 |
| http://purl.uniprot.org/citations/16186799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16186799 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_B0AZV6-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_B4E082-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_L0R6N5-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_Q2TAM5-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_O75368-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_P78359-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_Q04206-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_Q13313-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_Q96CP1-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |
| http://purl.uniprot.org/uniprot/#_Q96F54-mappedCitation-16186799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16186799 |