| http://purl.uniprot.org/citations/16186819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16186819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16186819 | http://www.w3.org/2000/01/rdf-schema#comment | "Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca(2+) ions and 18 disulfide bonds. The structure suggests how genetic alterations of THBSs result in disease."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb997"xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb997"xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Keck J.L."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Keck J.L."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Bernstein D.A."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Bernstein D.A."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Mosher D.F."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Mosher D.F."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Annis D.S."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Annis D.S."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Carlson C.B."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Carlson C.B."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Hannah B.L."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Hannah B.L."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Misenheimer T.M."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/author | "Misenheimer T.M."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/pages | "910-914"xsd:string |
| http://purl.uniprot.org/citations/16186819 | http://purl.uniprot.org/core/pages | "910-914"xsd:string |