| http://purl.uniprot.org/citations/16188233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16188233 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the expression of KIT (product of c-kit oncogene), gain-of-function mutations, and activation of its downstream signal transduction in human testicular cancers. KIT was expressed in 88% (22/25) of seminomas and in 44.4% (4/9) of non-seminomas compared to adjacent normal testicular tissue. Nine of the KIT-expressing seminomas had mutations (40.9%; 9/22) in the c-kit gene; two cases in exon 11 and 7 cases in exon 17. Two of these mutations in exon 17 were novel, and the other seven mutations were identical to the already known gain-of-function mutations which cause activation of KIT without ligand stem cell factor. All of the mutant KIT and 53.8% (7/13) of wild-type KIT were phosphorylated (activated) and associated with phosphorylated phosphatidylinositol 3-kinase (PI3K). Akt was also phosphorylated in these seminomas, suggesting that the KIT-PI3K-Akt pathway is activated in seminoma. These findings suggest that the KIT-PI3K-Akt pathway is constitutively activated in testicular germ cell tumors, due to overexpression of KIT protein and/or gain-of-function mutations in the c-kit gene."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.09.042"xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Arai Y."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Inoue H."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Miki T."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Nakai Y."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Nakayama M."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Nishimura K."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Mizutani Y."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Okuyama A."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Nonomura N."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Shiba M."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Aozasa K."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/author | "Oka D."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/pages | "289-296"xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/title | "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors."xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://purl.uniprot.org/core/volume | "337"xsd:string |
| http://purl.uniprot.org/citations/16188233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16188233 |
| http://purl.uniprot.org/citations/16188233 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16188233 |
| http://purl.uniprot.org/uniprot/#_A0A0U2N547-mappedCitation-16188233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16188233 |
| http://purl.uniprot.org/uniprot/#_A0A8I5KR87-mappedCitation-16188233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16188233 |
| http://purl.uniprot.org/uniprot/#_E2I6G0-mappedCitation-16188233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16188233 |