| http://purl.uniprot.org/citations/16195223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16195223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16195223 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases are activated by pleiotropic signals including environmental stresses, growth factors, and hormones. JNK-interacting protein 1 (JIP1) is a scaffold protein that assembles and facilitates the activation of the mixed lineage kinase-dependent JNK module and also establishes an interaction with beta-amyloid precursor protein that has been partially characterized. Here we show that, similarly to other proteins involved in various neurological diseases, JIP1 becomes hyperphosphorylated following activation of stress-activated and MAP kinases. By immobilized metal affinity chromatography and a combined microcapillary LC/MALDI-TOF/ESI-ion trap mass spectrometry approach, we identified 35 sites of mitotic phosphorylation within JIP1, among which eight were present within (Ser/Thr)-Pro sequence. This motif is modified by various kinases in aggregates of the microtubule-associated protein tau, which generates typical intraneuronal lesions occurring in Alzheimer disease. Most of the post-translational modifications found were located within the JNK, MAP kinase kinase, and RAC-alpha Ser/Thr protein kinase binding regions; no modifications occurred in protein Src homology 3 and phosphotyrosine interaction domains, which are essential for binding to kinesin, beta-amyloid precursor protein, and MAP kinase kinase kinase. Protein phosphorylation is known to affect stability and protein-protein interactions. Thus, the findings that JIP1 is extensively phosphorylated after activation of stress-activated and MAP kinases indicate that these signaling pathways might modulate JIP1 signaling by regulating its stability and association with some, but not all, interacting proteins."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m500226-mcp200"xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m500226-mcp200"xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Scaloni A."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Scaloni A."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "D'Adamio L."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "D'Adamio L."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Scheinfeld M.H."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Scheinfeld M.H."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "D'Ambrosio C."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "D'Ambrosio C."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Arena S."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Arena S."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Fulcoli G."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/author | "Fulcoli G."xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/name | "Mol. Cell. Proteomics"xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/name | "Mol. Cell. Proteomics"xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/pages | "97-113"xsd:string |
| http://purl.uniprot.org/citations/16195223 | http://purl.uniprot.org/core/pages | "97-113"xsd:string |