| http://purl.uniprot.org/citations/16198290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16198290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16198290 | http://www.w3.org/2000/01/rdf-schema#comment | "Centrosomes in mammalian cells have recently been implicated in cytokinesis; however, their role in this process is poorly defined. Here, we describe a human coiled-coil protein, Cep55 (centrosome protein 55 kDa), that localizes to the mother centriole during interphase. Despite its association with gamma-TuRC anchoring proteins CG-NAP and Kendrin, Cep55 is not required for microtubule nucleation. Upon mitotic entry, centrosome dissociation of Cep55 is triggered by Erk2/Cdk1-dependent phosphorylation at S425 and S428. Furthermore, Cep55 locates to the midbody and plays a role in cytokinesis, as its depletion by siRNA results in failure of this process. S425/428 phosphorylation is required for interaction with Plk1, enabling phosphorylation of Cep55 at S436. Cells expressing phosphorylation-deficient mutant forms of Cep55 undergo cytokinesis failure. These results highlight the centrosome as a site to organize phosphorylation of Cep55, enabling it to relocate to the midbody to function in mitotic exit and cytokinesis."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2005.09.003"xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2005.09.003"xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Ono Y."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Ono Y."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Nigg E.A."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Nigg E.A."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Sarcevic B."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Sarcevic B."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Graham M.E."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Graham M.E."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Robinson P.J."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Robinson P.J."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Khanna K.K."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Khanna K.K."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Fabbro M."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Fabbro M."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Gabrielli B.G."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Gabrielli B.G."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Lal P."xsd:string |
| http://purl.uniprot.org/citations/16198290 | http://purl.uniprot.org/core/author | "Lal P."xsd:string |