| http://purl.uniprot.org/citations/16198291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16198291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16198291 | http://www.w3.org/2000/01/rdf-schema#comment | "The C. elegans somatic gonadal precursor cell (SGP) divides asymmetrically to establish gonad-specific coordinates in both sexes. In addition, the SGP division is sexually dimorphic and initiates sex-specific programs of gonadogenesis. Wnt/MAPK signaling determines the gonadal axes, and the FKH-6 transcription factor specifies the male mode of SGP division. In this paper, we demonstrate that C. elegans cyclin D controls POP-1/TCF asymmetry in the SGP daughters as well as fkh-6 and rnr expression in the SGPs. Although cyclin D mutants have delayed SGP divisions, the cyclin D defects are not mimicked by other methods of retarding the SGP division. We find that EFL-1/E2F has an antagonistic effect on fkh-6 expression and gonadogenesis, which is relieved by cyclin D activity. We propose that cyclin D and other canonical regulators of the G1/S transition coordinate key regulators of axis formation and sex determination with cell cycle progression to achieve the sexually dimorphic SGP asymmetric division."xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2005.09.004"xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2005.09.004"xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/author | "Tilmann C."xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/author | "Tilmann C."xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/pages | "489-499"xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/pages | "489-499"xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/title | "Cyclin D regulation of a sexually dimorphic asymmetric cell division."xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/title | "Cyclin D regulation of a sexually dimorphic asymmetric cell division."xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/16198291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16198291 |
| http://purl.uniprot.org/citations/16198291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16198291 |
| http://purl.uniprot.org/citations/16198291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16198291 |
| http://purl.uniprot.org/citations/16198291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16198291 |
| http://purl.uniprot.org/uniprot/Q9XTR1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16198291 |
| http://purl.uniprot.org/uniprot/Q9U2M5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16198291 |